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    The majority of patients and doctors in Iran still prefer to consume the brand-name drugs for treatment of various diseases. Sertraline-HCl is one of the drugs that the generic and brand-name ones distribute widely in the market. In this study, drug product specifications such as content uniformity, uniformity of mass, dissolution test including dissimilarity (F) and dissolution efficiency (DE%) values of 8 generic and 3 brands of sertraline-HCl tablets (100 mg) were compared. Regarding to the results, relative standard deviation (RSD) ranges of weight variation test for generic and brand-name samples were 0.88 to 3.43% and 0.70 to 1.22%, respectively. For the amount of active pharmaceutical ingredient (API) per tablet RSD were 4.27 to 28.08% and 4.10 to 4.72%, respectively. Moreover, F in dissolution test indicated the lack of similarity between generic and brand-name ones. In the case of DE%, there was similarity between brand-name samples while most of the generic drugs showed less DE% (PCopy the following to cite this article: Tajani A. Generic drugs' hidden downside - latimes cheapest place for doxycycline Sertraline - Pharmaceutical Benefits Scheme PBS Zoloft sertraline Side Effects, Interactions, Uses & Drug.
     
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