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Use: For the treatment of documented Pneumocystis jiroveci pneumonia -Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet) orally once a day -Maximum dose: The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim Use: For prophylaxis against P jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P jiroveci pneumonia Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg orally every 12 hours for 10 to 14 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for up to 14 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Use: For the treatment of severe or complicated urinary tract infections due to susceptible strains of Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, and Proteus vulgaris Oral: Sulfamethoxazole-trimethoprim 800 mg-160 mg (1 double strength tablet or 2 single strength tablets) orally every 12 hours for 5 days IV: Severe infection: 8 to 10 mg/kg/day (based on the trimethoprim component) IV in 2 to 4 equally divided doses every 6, 8, or 12 hours for 5 days; maximum recommended dose is 960 mg (based on the trimethoprim component) per day Comments: -The patient should be instructed to use extraordinary sanitary precautions since Shigella is transmitted by the fecal-oral route, primarily by hand-to-mouth contact. 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