Primaquine kills the liver stages, known as hypnozoites, of these forms of malaria, preventing relapse of infection later on. However, primaquine is known to cause severe haemolytic anaemia in people who are G6PD deficient. Plaquenil and diarrhea and weight loss Chloroquine phosphate synthesis Synonyms G6PD/G-6-PD deficiency, non-spherocytic haemolytic anaemia The enzyme glucose-6-phosphate dehydrogenase G6PD is one of the enzymes of the pentose phosphate pathway. This pathway is involved in keeping an adequate amount of the coenzyme nicotinamide adenine dinucleotide phosphate NADPH in cells. Antimalarial drugs that can cause acute hemolysis in people with G6PD deficiency include primaquine, pamaquine, and chloroquine. There is evidence that other antimalarials may also exacerbate G6PD deficiency, but only at higher doses. For all uses of chloroquine Tell all of your health care providers that you take chloroquine. A severe eye problem has happened with chloroquine. Have an eye exam as you have been told by your doctor. Be careful if you have G6PD deficiency. Have your blood work checked if you are on chloroquine for a long time. Patients with severe G6PD deficiency should not take primaquine; unfortunately at this stage there are no alternative drug regimens available. G6PD deficiency is restricted to certain populations or segments of populations; therefore it may be that not every person requiring primaquine will be tested for their G6PD status, only those considered high risk for potential deficiency. Is chloroquine safe for g6pd deficiency Origins and implications of neglect of G6PD deficiency and., Glucose-6-phosphate dehydrogenase deficiency - Wikipedia Plaquenil rash wont go awayChloroquine maculopathyWhat is hydroxychloroquine is forTest for plaquenil retinopathyHydroxychloroquine sulfate and sun exposure Background/Purpose Hydroxychloroquine HCQ is frequently used to treat autoimmune diseases. The HCQ package insert and online drug information resources report an increased risk of hemolytic anemia in patients with G6PD deficiency. However, no published studies quantify this potential risk. Hydroxychloroquine Is Not Associated with Hemolytic Anemia in.. Chloroquine Indications, Side Effects, Warnings -. Who should not take Chloroquine Phosphate? - WebMD. Other Interactions. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Glucose-6-phosphate dehydrogenase G6PD deficiency—May cause hemolytic anemia in patients with this condition. Kidney disease or; Liver disease—Use with caution. The effects may be increased because of the slower removal of chloroquine from the body. Primaquine should not be prescribed for patients with severe G6PD deficiency see CONTRAINDICATIONS. In case of mild to moderate G6PD deficiency, a decision to prescribe Primaquine must be based on an assessment of the risks and benefits of using Primaquine.