If hydroxychloroquine was ineffective would it be effective with methotrexate

Discussion in 'Without A Doctor Prescription' started by RA Optimus, 26-Feb-2020.

  1. Dip XenForo Moderator

    If hydroxychloroquine was ineffective would it be effective with methotrexate


    It's the first drug most doctors prescribe after you’re diagnosed. It will help ease symptoms like joint pain, fatigue, redness, and swelling.

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    In hydroxychloroquine group, only erythema P = 0.004 showed significant improvement. Conclusions Methotrexate was more effective than hydroxychloroquine in treating refractory lichen planopilaris. Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Keystone E, Heijde D, Mason D, Jr, et al. Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

    Methotrexate interrupts the process that causes RA inflammation, which damages your joints and organs over time. It may also help prevent damage to your organs and joints.

    If hydroxychloroquine was ineffective would it be effective with methotrexate

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  5. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks

    • Does anyone take methotrexate and hydroxychloroquine..
    • Pharmacotherapy Options in Rheumatoid Arthritis.
    • Which would you pick and why? - Plaquenil or Methotrexate.

    I started on 10mg methotrexate and am now on 20mg. I have my. Fingers crossed that it is now finally working but am now suffering from lots of fungal rashes, lovely. This can be an issue with people on immune suppressing medication. so "Dr Google" advises. Best wishes and ask for steroid tablets until the methotrexate is effective. Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Hydroxychloroquine HCQ is a drug used to treat RA. It can reduce inflammation in several ways. It is commonly used to treat diseases where there is systemic whole body inflammation. It may protect against organ damage and bone mass loss. HCQ has been used in RA treatment for many years. However, more effective RA drugs have been developed.

     
  6. kpumuk New Member

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Sjögren Syndrome Patients Show Signs of Hearing Loss, Study Finds The "huge connection" between Lyme disease and hearing loss When to Report Reactions to Plaquenil
     
  7. anderw New Member

    Drug induced maculopathy - EyeWiki Established maculopathy - moderate reduction VA 6/18-6/24, Bull’s eye lesion in the macula Severe maculopathy - marked reduction VA 6/36-6/60, widespread RPE atrophy surrounding the fovea End stages - severe reduction VA marked RPE atrophy with unmasking of choroidal vessels peripheral pigment irregularity with bone spicule formation, vascular attenuation & optic disc pallor.

    What Eye Problems and Conditions Are Associated With Lupus?
     
  8. Chalet Well-Known Member

    APO-Hydroxychloroquine Tablets - NPS MedicineWise Hydroxychloroquine helps most people with rheumatoid arthritis, SLE, DLE, treatment of malaria and the control of malaria symptoms, but it may have unwanted side effects in a few people. You may need medical treatment if you get some of the side effects. Ask your doctor or pharmacist to answer any questions you may have.

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