Levothyroxine is a synthetic form of the thyroid hormone thyroxine (T4) that's used to treat an underactive thyroid, known as hypothyroidism. It's the most commonly prescribed medication in the United States, with around 123 million prescriptions written in 2016. There's a great deal of misinformation regarding the safety and effectiveness of generic levothyroxine as compared to brand names like Synthroid. Here's what you need to know about taking generic levothyroxine to treat your hypothyroidism. Generic levothyroxine is just as safe as the brand names—in the United States, these include Synthroid, Levoxyl, Unithroid, and Tirosint—because it has the same FDA-approved active ingredient (levothyroxine). That said, some people are sensitive to the fillers and additives found in the inactive ingredients of levothyroxine, such as gluten, dyes, and lactose. If you're not sure what your prescription's ingredients contain, ask your pharmacist for a list. Even though Synthroid and Levothyroxine contain the same active ingredient, they may not be tolerated equally among all patients. This means that certain patients do better on one medication compared to the other! Learn how to identify if you are taking the right type of medication and when to consider switching in this post: The most common medication used to treat hypothyroidism is Levothyroxine. Levothyroxine is considered a "generic" version of the thyroid medication Synthroid. But is there a difference and does it actually matter? Generic medications are usually created after a brand name medication goes off patent. Other pharmaceutical companies can then come in and make a "me too" version of the medication and they often sell it for cheaper than the original. In this case, we have Levothyroxine which is the generic and Synthroid which is the brand name medication. 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