In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Chloroquine in liver What is hydroxychloroquine taken for Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It should be noted, however, that most studies investigating the use of mfERG in HCQ toxicity have compared with SLE patients not taking HCQ or healthy controls and not with patients with other causes of macular pathology. a review of the literature on the use of hydroxychloroquine in renal impairment. Case Rep Ophthalmol Med. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Does hydroxychloroquine have renal toxicity Will you have Acute kidney failure with Hydroxychloroquine., Hydroxychloroquine-related retinal toxicity Rheumatology. Does plaquenil make your skin darkCurvilinear bodies hydroxychloroquine cardiomyopathy Individuals beginning HCQ therapy should be informed of the possibility, although extremely rare, of retinal toxicity, and told that periodic monitoring can lead to early recognition of some symptoms. Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Hydroxychloroquine Plaquenil Toxicity and.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Both chloroquine and hydroxychloroquine have excellent oral absorption and bioavailability. Both have a long and variable plasma elimination half-life because of a high volume of distribution, an extended mean residence time HCQ 1300 hours and CQ 900 hours and with about half the drug metabolites undergoing unmodified renal clearance. How does lupus affect the renal kidney system? Lupus is an autoimmune disease that can affect almost any part of your body, most often your joints, skin, kidneys, heart, lungs, blood, or brain. Your two kidneys are part of your renal system, which also includes two ureters, the bladder, and the urethra.