Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Starting hydroxychloroquine Hydroxychloroquine cancer stem cells Hydroxychloroquine and prednisone Chloroquine or proguanil Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Although Plaquenil is an older drug, it is still available and prescribed to some people who have rheumatoid arthritis or certain other rheumatic diseases. Plaquenil is a DMARD which has been prescribed for years to treat rheumatoid arthritis, lupus, juvenile rheumatoid arthritis, and other autoimmune diseases. Kidney failure. Kidney failure refers to a decrease in kidney function and one of the most common causes of high creatinine. It can be either acute or chronic. The symptoms of acute kidney failure. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Can plaquenil cause kidney problems Symptoms of Kidney Disease Kidney Disease Info, Taking Plaquenil for Rheumatoid Arthritis Cerebral malaria lithium and plaquenilSide effects of plaquenil depression In summary Plaquenil isn't causing tyour new problems. It probably caused only the nausea, diarrhea, stomach cramps, and intense vertigo. BTW 100 mg daily may reduce side effects, but this low dosage also greatly annihilates its positive effects. 100 mg are a drop maybe two. on a hot stone Plaquenil side effects - kidney problems? - Symptoms.. High Creatinine Symptoms What May Occur When Your Levels Are Off. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Hi gonebananas, not sure if this will answer your question but it is very possible to be in a flare and not have a positive ANA. I have never had a positive ANA maybe once? in 12 years with lupus and mine is lupus nephritis so kidney involvement. Wasn’t positive before Plaquenil and isn’t positive now. One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. What Is Plaquenil? Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil is available in generic form.