Chloroquine treatment and virus infection

Discussion in 'Pharmacy Northwest Canada' started by aando, 08-Mar-2020.

  1. kryzander XenForo Moderator

    Chloroquine treatment and virus infection


    In a three-page paper published in Cell Research, scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology wrote that both Chloroquine and the antiviral Remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. According to the paper, an efficient approach to drug discovery is to test whether the existing antiviral drugs are effective in treating related viral infections.

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    Chloroquine, a widely-used anti-malarial and autoimmune disease drug, has recently been reported as a potential broad-spectrum antiviral drug. 8,9 Chloroquine is known to block virus infection by. Chloroquine can affect virus infection in many ways, and the antiviral effect depends in part on the extent to which the virus utilizes endosomes for entry. Chloroquine has been widely used to treat human diseases, such as malaria, amoebiosis, HIV, and autoimmune diseases, without significant detrimental side effects 15. Chloroquine is cheap and has been on the market for many years. It therefore may potentially be a good treatment option until a vaccine against the coronavirus is available. Chloroquine has been marketed internationally since 1934 as an antimalarial treatment.

    Among the tested drugs, two compounds – remdesivir and chloroquine – potently blocked virus infection at low-micromolar concentration and showed high SI, it was revealed. Several FAD-approved drugs were tested, including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir and favipiravir against a clinical isolate of 2019-n Co V (coronavirus) in vitro.

    Chloroquine treatment and virus infection

    Management of Patients with Confirmed 2019-nCoV CDC, Chloroquine is a potent inhibitor of SARS coronavirus.

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  7. Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria.

    • Could an old malaria drug help fight the new coronavirus?.
    • Malaria drug chloroquine potential treatment for coronavirus.
    • Remdesivir for the treatment of coronavirus infection News..

    Spectrum antiviral drug.8,9 Chloroquine is known to block virus infection by increasing endosomal pH required for virus/ cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV.10 Our time-of-addition assay demon-strated that chloroquine functioned at both entry, and at post- Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. You should know that the 150mg base tablet is the same as the 250mg salt tablet and the 300mg base. tablet is the same as the 500mg salt tablet. It is just two different ways of describing the same thing. Chloroquine can be prescribed for either prevention or treatment of malaria.

     
  8. PliKo XenForo Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Plaquenil Prices, Coupons & Patient Assistance. - Hydroxychloroquine Prices, Coupons & Patient. - Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  9. luciff Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Chloroquine Oral Uses, Side Effects, Interactions. Lariago 250 mg Chloroquine Dose, Side effects, Barnd. Chloroquine or Malarone. - Punta Cana Forum - Tripadvisor
     
  10. oval XenForo Moderator

    Taking Plaquenil for Rheumatoid Arthritis The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs.

    Recommendations on Screening for Chloroquine and Hydroxychloroquine.