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    Article date: February 2010 Orlistat is a potent, specific, and long-acting inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by preventing the gastric and pancreatic lipases from hydrolysing dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides. Orlistat is available in Europe as 120 mg capsules under the brand name Xenical, and as 60 mg capsules under the brand name alli, for weight loss in combination with a reduced-calorie, lower-fat diet. Xenical has been licensed since 1998 and is available as a prescription-only medicine; alli was licensed in January 2009 and is available without a prescription under the supervision of a pharmacist. A recent Europe-wide review of the safety information for alli has led to a number of updates, which bring the product information in line with that for Xenical. Pharmacists should be aware of this information so that they can appropriately advise consumers who wish to buy alli or discuss its use. If you have a prescription you will be required to send it to us before we can dispense. If you do not have a private prescription, select Supply me with a valid prescription and we will ask you to complete an online consultation once you have purchased. Our doctors will prescribe a maximum of 3 of this product or any equivalent product at a time. Xenical is a prescription only medicine used to treat obesity. Xenical is taken by mouth, 3 times a day and helps you lose 50% more weight than you would without it. Xenical works by preventing the body from absorbing about one-third of the fat in the food introduced. Xenical blocks the lipases (enzymes in the digestive system) from breaking down some of the fat and making it undigestable, letting the body eliminate it. You can buy UK sourced Xenical online from Pharmacy Direct GB.

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    Generic medicines contain the same active ingredient and are equally effective and medically equivalent as the branded products but are available at a lower price. Generic manufacturers have to demonstrate that they are medically identical to the branded product - i.e. they offer the same quality, strength, stability and effectiveness. Visit our Generic Medicine FAQ for more information Xenical (Orlistat 120mg) is used in the treatment of obesity. Xenical prevents your body from absorbing the fat from the food you eat. By reducing the amount of fat that is absorbed, Xenical can help you to lose weight more easily. When you start taking Xenical you will be given a weight loss target for the first 3 months. If you succeed in losing 5% of your weight, you will be eligible to continue taking Xenical. Orlistat is the only medicine currently licensed in the EU to help you lose weight. Orlistat prevents your body from absorbing the fat from the food you eat. By reducing the amount of fat that is absorbed, Orlistat is clinically proven to help you lose up to 50% more weight than with dieting alone. Generic medicines contain the same active ingredient and are equally effective and medically equivalent as the branded products but are available at a lower price. Generic manufacturers have to demonstrate that they are medically identical to the branded product - i.e. they offer the same quality, strength, stability and effectiveness. Visit our Generic Medicine FAQ for more information Orlistat 120mg is used in the treatment of obesity.

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breast (fibrocystic disease, breast carcinoma); endometrium (endometrial carcinoma); nervous system (astrocytoma, pituitary tumor, prolactinoma, neurofibromatosis, glioblastoma multiforme, brain abscess); ovary (luteoma of pregnancy, dermoid cyst of the ovary, ovarian carcinoma); trophoblastic (hydatiform mole, choriocarcinoma); miscellaneous (melanoma, myeloma, perianal cysts, renal cell carcinoma, Hodgkin’s lymphoma, tongue carcinoma, bladder carcinoma) Psychiatric: Anxiety, irritability, mood changes, psychosis Visual disorders: Abnormal accommodation, cataract, eye pain, macular edema, optic neuritis, photopsia, posterior vitreous detachment, retinal hemorrhage, retinal thrombosis, retinal vascular spasm, temporary or prolonged loss of vision, possibly irreversible Metabolism disorders: Hypertriglyceridemia Other: Leukocytosis, thyroid disorder Careful attention should be given to selection of candidates for therapy; pelvic examination is necessary prior to treatment and before each subsequent course Uterine fibroids, pituitary or ovarian failure may occur Risk of ovarian enlargement & ovarian hyperstimulation syndrome (OHSS); transient liver function test abnormalities suggestive of hepatic dysfunction, which may be accompanied by morphologic changes on liver biopsy, reported in association with OHSS, which is a medical event distinct from uncomplicated ovarian enlargement; death due to hypovolemic shock, hemoconcentration, or thromboembolism has occurred; if enlargement of ovary occurs, additional therapy should not be given until ovaries have returned to pretreatment size, and dosage or duration of next course should be reduced; ovarian enlargement and cyst formation associated with therapy usually regresses spontaneously within a few days or weeks after discontinuing treatment; potential benefit of subsequent therapy in these cases should exceed risk Potential for multiple births, especially at 100 mg dosage Risk of visual disturbance (like scotoma & photopsia); patients should be warned that visual symptoms may render activities such as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting; while etiology of visual symptoms is not yet understood, patients with any visual symptoms should discontinue treatment and have complete ophthalmological evaluation carried out promptly Cases of hypertriglyceridemia reported; preexisting or family history of hyperlipidemia and use of higher than recommended dose and/or longer duration of treatment are associated with risk of hypertriglyceridemia; periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia; pretreatment screening of triglyceride levels is recommended in patients initiating therapy Cases of pancreatitis reported Prolonged use of clomiphene citrate tablets USP may increase risk of a borderline or invasive ovarian tumor Use in pregnant women is contraindicated, as treatment does not offer benefit in this population; to avoid inadvertent administration during early pregnancy, appropriate tests should be utilized during each treatment cycle to determine whether ovulation and/or pregnancy occurs; patients should be evaluated carefully to exclude ovarian enlargement or ovarian cyst formation between each treatment cycle; the next course of therapy should be delayed until these conditions have been excluded Available human data from epidemiologic studies do not show apparent cause and effect relationship between clomiphene citrate periconceptual exposure and an increased risk of overall birth defects, or any specific anomaly It is not known whether drug is excreted in human milk; because many drugs are excreted in human milk, caution should be exercised if drug is administered to a nursing woman; in some patients, therapy may reduce lactation Half-Life elimination: 5-7 days Onset: Within 5-10 days Peak plasma time 6.5 hours Bioavailability: Readily absorbed from GI tract Metabolism: Enterohepatically circulated Excretion: feces 37-51%; small amount in urine The above information is provided for general informational and educational purposes only. 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