Mechanism of chloroquine resistance

Discussion in 'Online Canadian Pharmacy' started by dumanyan liya, 18-Mar-2020.

  1. JamaL Moderator

    Mechanism of chloroquine resistance


    Resistance to currently available antimalarial drugs has been confirmed in only two of the four human malaria parasite species, first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted.

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    Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. The spread of chloroquine resistance poses a serious challenge to find strategies to treat malaria. an understanding of the molecular mechanisms involved in chloroquine resistance can lead to.

    Although resistance to these drugs tends to be much less widespread geographically, in some areas of the world, the impact of multi-drug resistant malaria can be extensive. Has also developed resistance to nearly all of the other currently available antimalarial drugs, such as sulfadoxine/pyrimethamine, mefloquine, halofantrine, and quinine.

    Mechanism of chloroquine resistance

    Mechanisms of drug action and resistance, On the Mechanism of Chloroquine Resistance in Plasmodium falciparum.

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  5. Resistance to chloroquine of malaria strains is known to be associated with a parasite protein named PfCRT, the mutated form of which is able to reduce chloroquine accumulation in the digestive vacuole of the pathogen. Whether the protein mediates extrusion of the drug acting as a channel or as a carrier and which is the protonation state of its chloroquine substrate is the subject of a.

    • On the Mechanism of Chloroquine Resistance in Plasmodium falciparum.
    • Molecular mechanisms involved in chloroquine resistance..
    • Drug resistance in malaria - World Health Organization.

    The molecular mechanism of resistance development to chloroquine is still not well understood. It is critical that its mechanism of action be well understood as it is a safe drug, well tolerated in the body and it is further moderately affordable 6. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved. Research on the mechanism of chloroquine and how the parasite has acquired chloroquine resistance is still ongoing, as other mechanisms of resistance are likely. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance Science Chloroquine-resistant Plasmodium falciparum accumulate significantly less chloroquine than.

     
  6. Sham021 Moderator

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  7. Azizov Guest

    Hydroxychloroquine Sulfate Sandoz Inc FDA Package Insert Hydroxychloroquine sulfate should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects Dermatologic reactions to hydroxychloroquine sulfate may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant.

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  8. 4LF Moderator

    Levaquin Levofloxacin Uses, Dosage, Side Effects. Oct 29, 2018 Levaquin Levofloxacin may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

    Hydroxychloroquine Oral Route Before Using - Mayo Clinic