ANSWER Chloroquine-resistant malaria is exactly what it sounds like—particular types of malaria which are not cured by treatment with chloroquine. Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. What is another name for hydroxychloroquine Half life of hydroxychloroquine The location of study sites with documented chloroquine resistance and chloroquine sensitive P. vivax is shown in Figure 2a and for chloroquine sensitive sites in Figure 2b below. Estimates for chloroquine sensitivity derived from 112 sites. In 50.9% of the sites estimates P. vivax were categorized as resistant. Read the original article in full on AAS Open Research Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana Of drug resistance including its determinants, current status in diverse geographical areas, molecular markers and their implications to limit the advent, spread and intensification of drug resistant malaria. Key words Chloroquine-resistant malaria – molecular markers – pfmdr-1 polymorphism – sulphadoxine & pyrimethamine Since then, resistance has spread rapidly (since obviously it is beneficial to the parasite to be resistant, so various mutations conferring this protection have arisen multiple times in different areas in the world and also been passed on preferentially to new generations of malaria parasites), and now chloroquine resistant are found in multiple locations in south-east Asia, such as Myanmar and India, as well as from Guyana in South America. However, resistance to the drug also rapidly emerged, with the first cases of not being cured by administration of chloroquine being reported in the 1950s. Chloroquine resistance areas Drug Resistance in the Malaria-Endemic World, Prevalence of chloroquine and antifolate drug resistance. Effect of chloroquine injection on early pregnancy Chloroquine resistance was demonstrated for the first time in semi-immune Tanzanians in 1982. 11 The following year, a chloroquine resistance rate of 34% was reported among a Zanzibar school population. 12 Studies conducted between 19 in various areas of the country indicated that the median in vivo resistance rate in school children. The Public Health Impact of Chloroquine Resistance in Africa.. Drug resistance in malaria - National Institute of Malaria.. Epidemiology of drug-resistant malaria - The Lancet.. Areas with Malaria Drug Resistance 2 Malaria Species 3 Recommended Chemoprophylaxis 4 Key Information Needed and Helpful Links to Assess Need for Prophylaxis for Select Countries; Cambodia Present throughout the country, including Siem Reap city. None in the city of Phnom Penh or at the temple complex at Angkor Wat. Chloroquine Mefloquine. P. Drug resistance has been implicated in the spread of malaria to new areas and re-emergence of malaria in areas where the disease had been eradi-cated. Drug resistance has also played a significant role in the occurrence and severity of epidemics in some parts of the world. Population movement has introduced resistant parasites to areas. The term “chloroquine resistance” can lead to misunderstandings when it is considered by some to refer to in vitro phenotypes, by others to refer to the ability of malaria parasites to survive chloroquine at therapeutic serum concentrations in vivo, and yet by others to refer to the outcome of a clinical episode after chloroquine therapy.