The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. Weight gain with plaquenil Does plaquenil affect blood pressure If you have chikungunya, prevent mosquito bites for the first week of your illness. During the first week of infection, chikungunya virus can be found in the blood and passed from an infected person to a mosquito through mosquito bites. An infected mosquito can then spread the virus to other people. Despite its antiviral potential, oral chloroquine treatment for five days in patients with acute chikungunya did not protect against severe disease. Despite its antiviral potential, oral. In their Review on chikungunya, Gilles Pialoux and colleagues1 quote a Reflection and Reaction commentary previously published by our group2 as the source for the statement that “a clinical trial in South Africa failed to confirm the clinical efficacy of chloroquine on arthralgia”. It is true that chloroquine displays antiviral and anti-inflammatory properties that, in our opinion, merit. However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. On chikungunya acute infection and chloroquine treatment Targeting endosomal acidification by chloroquine analogs as a., On Chikungunya Acute Infection and Chloroquine Treatment. Hydroxychloroquine sulphate tablets zy-q 300Plaquenil sjogren& 39 The single patient of the current study who initially received a 14-day chloroquine treatment improved in locomotion, but became symptom-free only after 6 months. Controlled studies are being conducted in Reunion to evaluate the efficacy of early chloroquine treatment in CHIKV infection de Lamballerie, personal data. Chikungunya Infection An Emerging Rheumatism Among.. On the use of chloroquine for chikungunya - The Lancet.. On chikungunya acute infection and chloroquine treatment.. Chikungunya virus infection CHIKV is caused by a mosquito-borne alphavirus. CHIKV causes high fever and painful rheumatic disorders that may persist for years. Because little is known about interventions for treating CHIKV-related illness, we conducted a systematic review. Due to the alkalisation of endosomes, chloroquine was an effective in vitro treatment against Chikungunya virus when added to Vero cells prior to virus exposure. The mechanism of inhibition likely involved the prevention of endocytosis and/or rapid elevation of the endosomal pH and abrogation of virus–endosome fusion. Sep 15, 2009 Treatment for chikungunya fever is limited to supportive care rest, fluids, antipyretics, and analgesics. Although there have been in vitro studies and limited clinical data suggesting a role for certain drugs, such as chloroquine, acyclovir, ribavirin, interferon-α, and corticosteroids.