One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil toxicity lips Hydroxychloroquine cornea What is hydroxychloroquine made of Jan 18, 2019 Hydroxychloroquine Plaquenil was originally used to treat malaria and is now used mostly to treat rheumatological and dermatological diseases. Its most frequent use now is for Rheumatoid Arthritis RA and Lupus and is often very effective in mitigating the joint and arthritic symptoms these diseases can cause. Plaquenil can cause serious vision problems that aren't always reversible. Tell your doctor immediately if you notice any changes in vision or if you've ever had vision changes while taking. Hydroxychloroquine HCQ is a 4-aminoquinoline which differs from chloroquine CQ in the addition of a hydroxyl group. Initially used as antimalarials, both drugs have now become mainstays in the management of rheumatic diseases principally systemic lupus erythematosus SLE and rheumatoid arthritis RA. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity reversible Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS, Plaquenil Hydroxychloroquine - Side Effects, Dosage. Aralen malaria medicationHydroxychloroquine in lupus nephritisPlaquenil time to workPlaquenil maintenance dosePlaquenil e nausea The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin -containing structures in the body. With prolonged usage, metabolites in the drug accumulate in the retina. The drug remains in these parts even if the patients stopped taking the drugs. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Hydroxychloroquine cardiotoxicity presenting as a rapidly.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Dec 28, 2017 I haven't had any issues with Plaquenil, and I've been on it for 13 years. Be sure you get your eyes checked regularly for Plaquenil toxicity, a very rare side effect that can affect your vision, but is usually reversible if caught early. I know Plaquenil has helped me a ton, because I tried going off of it once to see if I really needed it. Deferoxamine toxicity is reversible with drug cessation, with full recovery of visual function. However, the medication is often used for chronic conditions, such as thalassemia, that require regular therapy. In these patients, monitoring with frequent ophthalmic exams is essential to detect early vision loss. Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito.