Azithromycin stability

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  1. arhil User

    Azithromycin stability


    The chemical stability of azithromycin (AZM) in aqueous solution has been investigated utilizing a stability-indicating LC assay with ultraviolet detection. The degradation kinetics were studied as functions of p H (4–7.2), buffer composition (phosphate, acetate, and citrate), buffer concentration, ionic strength, drug concentration and temperature. The observed rate obtained by measuring the remaining intact AZM was shown to follow pseudo-first-order kinetics. The maximum stability of AZM occured at an approximate p H 6.3 in 0.05 M potassium phosphate. The observed degradation rate increased with ionic strength, buffer concentration and obeyed the Arrhenius equation over the temperature range investigated (70–100 °C). The apparent energy of activation () had been predicted. Moreover, the degradation rate of AZM was independent on its initial concentration. The stability of an antibiotic depends on its chemical structure, method of isolation (from natural sources or chemical synthesis), and the mechanisms of inactivation. First generation antibiotics isolated from natural sources, such as penicillin, are the most unstable, followed by its semisynthetic derivatives (such as ampicillin and carboxycylin). Aminoglycosides (kanamicin, spectinomycin, etc.) are more stable. So what does this mean for antibiotic storage and usage in the lab? Food Additives & Contaminants: Part A, Volume 28, Issue 12, 2011 Kenneth J. Determination of the stability of antibiotics in matrix and reference solutions using a straightforward procedure applying mass spectrometric detection. Stability of Antibiotics and Chemotherapeutics in Agar Plates.

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    Transfer 5 mL of the 100 mg/mL azithromycin reconstituted solution into the appropriate. azithromycin for injection is stable for 24 hours at or below room. A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the. A stability study of azithromycin in ophthalmic preparations was developed by submission to different types of light, temperature and pH, using the biodiffusion.

    Azithromycin, produced by Pfizer under the brand name Zithromax or Azitrocin, has emerged as a very valuable antibiotic for the treatment of various infections in the cat. It is well tolerated, even by young kittens, and its efficacy in the treatment of upper respiratory infections (including bordetella and chlamydia), in particular, is unequalled by other anitbiotics. It is cleared very slowly from feline tissue, resulting in dosage schedules that are very convenient for the cat owner. A single dose maintains effective drug levels in the cat's tissues for as long as a week. The correct dose for the use of azithromycin in cats is 5 mg/kg (5 mg of drug for every 2.2 pounds of cat or 2.3 mg per pound of cat). Because of the persistance of this drug in feline tissues, DO NOT try to translate any protocol given for the use of this drug in humans and try to apply it to your cat. This mistake has been made by numerous veterinarians and pharmacists. The degradation profile of azithromycin in buffered solutions was investigated using HPLC and found to be p H dependent in the range of 6.0–7.2. Desosaminylazitromycin, derived from hydrolytic loss of cladinose of the parent molecule, was the major degradation product at p H 6.0 but its amount progressively decreased moving toward p H 7.2. Two additional unreported degradation products were also observed and their structures were fully elucidated by MS- and NMR-spectroscopy to be associated with opening of the macrocyclic lactone ring.

    Azithromycin stability

    Antibiotic Stability Keep Your Gunpowder Dry - Bitesize Bio, Stability study of azithromycin in ophthalmic

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  7. Azithromycin 1 is a semi-synthetic macrolide antibiotic with a broad spectrum of activity against a variety of Gram-positive and Gram-negative bacteria. Azithromycin has been widely used since mid 80′s in clinical treatment of respiratory infections and sexually transmitted diseases.

    • PH-Dependent stability of azithromycin in aqueous solution..
    • Stability study of azithromycin in ophthalmic preparations - SciELO.
    • JOHORE ANTIBIOTICS DILUTION QUICK REFERENCE 2011.

    Azithromycin is a macrolide antibiotic ATC classification J01FA10 belonging to. dilution to a final infusion concentration of 1 or 2 mg/ml prior to. The aim of this paper was to describe the temperature effect on the stability and the thermophysical properties of azithromycin AZ. First, the density, the heat. J Pharm Biomed Anal. 2018 Sep 5;1-53. doi 10.1016/20. Epub 2018 May 28. pH-Dependent stability of azithromycin in aqueous solution.

     
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