Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine diphosphate side effects Plaquenil and ovarian cancer Hydroxychloroquine and chloroquin sarcoidosis Serious side effects. blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or bruising. blue-black skin color. muscle weakness. hair. Side Effects. Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. My Mom's Dr's wan'ts her to take both Prednisone and Plaquenil together. I have not heard of this being done. I was wondering if anyone has done both med's at the same time and the effects. Mom has Lupus like me, but she was diagnosed when she was 40 yrs old and now she is 58. She has and enlarged heart, diabetes, had a stroke, and failing kidneys. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil and prednisone side effects Common and Rare Side Effects for Plaquenil Oral, Plaquenil Oral Uses, Side Effects, Interactions. Hydroxychloroquine sulphate and mecobalamin tabletsChloroquine pharmacokineticsChloroquine injection useSide effects of hydroxychloroquine and mycophenolate Plaquenil hydroxychloroquine Remove Plaquenil from your drug comparison. Prednisone Remove Prednisone from your drug comparison. Prescribed for Lyme Disease - Arthritis, Dermatomyositis, Malaria, Malaria Prevention, Rheumatoid Arthritis, Systemic Lupus Erythematosus. Plaquenil vs Prednisone Comparison -. Prednisone and plaquenil -. The Stranger Side Effects of Prednisone. Tell your doctor if you experience serious side effects of Plaquenil including muscle weakness, twitching, uncontrolled movement, loss of balance or coordination, blurred vision, light sensitivity, seeing halos around lights, pale skin, easy bruising or. bleeding, confusion, unusual. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. My question Do you feel like you've gained weight on Plaquenil ie without Prednisone? The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead.