She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Plaquenil for autoimmune hives Low-dose hydroxychloroquine in treatment of porphyria Although optic nerve and retinal imaging devices have been used to document the appearance of the optic nerve head and retina, there is a lack of evidence from prospective clinical studies demonstrating that clinical outcomes are improved by incorporating this technology into glaucoma screening. Large iron containing chronic intraocular foreign body with extensive siderosis of retina. The optic nerve is just to left of foreign body with extensive sheathing of retinal vessels. Imaging device Zeiss FF4. Condition/keywords intraocular foreign body, penetrating trauma, siderosis, trauma Purpose To investigate the choroidal changes that occur in hydroxychloroquine HCQ retinopathy using multimodal imaging including fluorescein angiography, indocyanine green angiography, and optical coherence tomography OCT angiography and to correlate these changes with retinal findings obtained using OCT and fundus autofluorescence. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal deposits plaquenil infared imaging Hydroxychloroquine retinopathy Eye, Miscellaneous - Retina Image Bank Hydroxychloroquine sulfate dosageChloroquine diphosphate salt msdsChloroquine phosphate overdoseHydroxychloroquine type 2 diabetes fdaPlaquenil dosage for osteoarthritis Jan 01, 2011 SriniVas Sadda, MD, is associate professor of ophthalmology at the Keck School of Medicine of the University of Southern California and the Doheny Eye is Director of the Medical Retina Unit, Ophthalmic Imaging Unit, Retinal Transplantation Laboratory and Digital Image Reading Center. Fundus Autofluoresence Imaging Principles and Applications. TOXIC EFFECTS OF HYDROXYCHLOROQUINE ON THE CHOROID. RETINA. THE VALUE OF RETINAL IMAGING WITH INFRARED SCANNING LASER.. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. The first reports concerned long-term use of CQ for malaria, and later reports showed retinopathy after treatment of anti-inflammatory diseases.1, 2 Chloroquine toxicity remains a problem in many parts of the world, but it is seen infrequently in the United States, where the. Sep 01, 2018 Over time, or with continued IV drug abuse, these deposits can lead to complications, such as retinal artery occlusion, neovascularization and vitreous hemorrhage, all of which can cause severe progressive vision loss. On SD-OCT, the crystalline deposits are observed as hyperreflective dots in the inner retina that distribute along the arteries. The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium RPE cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes.