Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Hydroxychloroquine blood monitoring Plaquenil and allergy testing Macular oct changes in plaquenil toxicity A low-dose chemotherapy drug; hydroxychloroquine; an anti-malaria drug; drugs like Enbrel; which are known as tumor-necrosis factor; or TNF; inhibitors; All of these medications can cause damage to the liver and increased liver enzymes. Let your physician know before starting these medications if you have any history of liver disease. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Chromatin 288 High. He is puzzled by this result so in comes the plaquenil. My liver enzymes are also elevated but I’m also taking Metformin 2,000 daily for 3 years now for Diabetes 2 and also have gallstones which are not giving me much problems as of yet. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil increase liver enzymes Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Side effects of hydroxychloroquine 400 mg Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. Hydroxychloroquine - Wikipedia. Mixing Mino with Plaquenil? - Road Back Foundation. Normalization of methotrexate-induced high levels of serum.. In these patients, high doses of hydroxychloroquine may trigger liver damage. 9, 10, 17 From the community “I was on Plaquenil for 5 1/2 yrs with no liver problems but had to stop it because it had started to affect my retinas.” - Inspire member “I take 200 mg of Plaquenil a day. I was told it can take months to help and it did. Hi Wimpy12 - I have PsA and my first biologic was Enbrel, along with Plaquenil. My doctor also tried adding in MTX, Arava, and several other DMARDS but my liver enzymes would rise. So used Enbrel alone and it worked great, have since switched to Cimzia and it is working good too. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.