Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Do you still have flare ups while taking hydroxychloroquine Can hydroxychloroquine affect memory Hydroxychloroquine ingredients Oct 30, 2008 Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years. She presented with a mottled, reticulated macular gray pigmentation involving the upper back and shoulders. Case 2 had a history of systemic lupus erythematosus and rheumatoid arthritis. The mechanism for hyperpigmentation is poorly understood. Risk factors appear to be linked to bruising, corticosteroid use, oral anticoagulants, antiplatelet agents, antiphospholipid syndrome and skin trauma.1 Histology usually shows superficial dermal deposition of brown-pigmented granules of iron or melanin, or both. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine pigmentation histology Hydroxychloroquine MedlinePlus Drug Information, Hydroxychloroquine-related skin discoloration CMAJ Plaquenil tablet usesEye exam before plaquenilHydroxychloroquine drug classTurmeric and plaquenilMethotrexate sulfasalazine hydroxychloroquine and leflunomide An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. Hydroxychloroquine induced cutaneous pigmentation a.. Skin Pigmentation with Hydroxychloroquine Plaquenil.. Hydroxychloroquine-induced hyperpigmentation in systemic.. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Common, usually harmless condition, in which patches of skin become darker than normal surrounding skin Wikipedia Due to melanocyte stimulation from drugs Merck, heat, hormones, inflammation eMedicine, malignancy, metabolic disease, scars, sunlight, various dermatoses or familial progressive hyperpigmentation Eur J Dermatol 2006;6 We report two cases of hydroxychloroquine-induced hyperpigmentation presenting in a 50-year-old Caucasian female case 1 and a 78-year-old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4-5 years.