Inderal migraine

Discussion in 'Canadian Prescription Drugs' started by qubit, 20-Aug-2019.

  1. Alexyz XenForo Moderator

    Inderal migraine


    The following information is NOT intended to endorse drugs or recommend therapy. My eye area, cheek and ear were always sensitive to touch. The nightmares were something else, 3 -4 times a month. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."Migraines started at age 50. I was actually afraid I would give my husband a heart attack when I would wake up screaming and thrashing at night. Sometimes I would feel slight pain behind my eye, but never needed pain reliever. When I hadn't felt that pain behind my eye for about a year, I gradually went off Inderol (around 60 yrs old).""I put on 40kg over the course of 12 years of this medication but I don't have migraines. The generic ones don't work at all except Derralin (can no longer get inderral in Australia) I would recommend anyone with life altering migraines to try it for 3 months. It just might be the cure you are waiting for.""I'm a 61 year old man, I took Inderal LA 60mg for a year. For about 8 months it worked well, migraines would start and then go away after 5 to minutes. Prophylaxis 80 mg/day PO divided q6-8hr initially; may be increased by 20-40 mg/day every 3-4 weeks; not to exceed 160-240 mg/day divided q6-8hr Inderal LA: 80 mg/day PO; maintenance: 160-240 mg/day Withdraw therapy if satisfactory response not seen after 6 weeks Hemangeol: Indicated for treatment of proliferating hemangioma requiring systemic therapy Initiate treatment at aged 5 weeks to 5 months Starting dose: 0.6 mg/kg (0.15 m L/kg) PO BID for 1 week, THEN increase dose to 1.1 mg/kg (0.3 m L/kg) BID; after 2 more weeks, increase to maintenance dose of 1.7 mg/kg (0.4 m L/kg) BID PO: 0.5-1 mg/kg/day divided q6-8hr; may be increased every 3-7 days; usual range: 2-6 mg/kg/day; not to exceed 16 mg/kg/day or 60 mg/day IV: 0.01-0.1 mg/kg over 10 minutes; repeat q6-8hr PRN; not to exceed 1 mg for infants or 3 mg for children PO: 1 mg/kg/day divided q6hr; after 1 week, may be increased by 1 mg/kg/day to maximum of 10-15 mg/kg/day if patient refractory; allow 24 hours between dosing changes IV: 0.01-0.2 mg/kg over 10 minutes; not to exceed 5 mg Immediate-release: 40 mg PO q12hr initially, increased every 3-7 days; maintenance: 80-240 mg PO q8-12hr; not to exceed 640 mg/day Inderal LA: 80 mg/day PO initially; maintenance: 120-160 mg/day; not to exceed 640 mg/day Inno Pran XL: 80 mg/day PO initially; may be increased every 2-3 weeks until response achieved; maintenance: not to exceed 120 mg/day PO Consider lower initial dose PO: 10 mg q6-8hr; may be increased every 3-7 days IV: 1-3 mg at 1 mg/min initially; repeat q2-5min to total of 5 mg Once response or maximum dose achieved, do not give additional dose for at least 4 hours Aggravated congestive heart failure Bradycardia Hypotension Arthropathy Raynaud phenomenon Hyper/hypoglycemia Depression Fatigue Insomnia Paresthesia Psychotic disorder Pruritus Nausea Vomiting Hyperlipidemia Hyperkalemia Cramping Bronchospasm Dyspnea Pulmonary edema Respiratory distress Wheezing Allergic: Hypersensitivity reactions, including anaphylactic/anaphylactoid; agranulocytosis, erythematous rash, fever with sore throat Skin: Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, urticaria Musculoskeletal: Myopathy, myotonia May exacerbate ischemic heart disease after abrupt withdrawal Hypersensitivity to catecholamines has been observed during withdrawal Exacerbation of angina and, in some cases, myocardial infarction occurrence after abrupt discontinuance When discontinuing long-term administration of beta blockers (particularly with ischemic heart disease), gradually reduce dose over 1-2 weeks and carefully monitor If angina markedly worsens or acute coronary insufficiency develops, reinstate beta-blocker administration promptly, at least temporarily (in addition to other measures appropriate for unstable angina) Warn patients against interruption or discontinuance of beta-blocker therapy without physician advice Because coronary artery disease is common and may be unrecognized, slowly discontinue beta-blocker therapy, even in patients treated only for hypertension Asthma, COPD Severe sinus bradycardia or 2°/3° heart block (except in patients with functioning artificial pacemaker) Cardiogenic shock Uncompensated congestive heart failure Hypersensitivity Overt heart failure Sick sinus syndrome without permanent pacemaker Do not use Inno Pran XL in pediatric patients Long-term beta blocker therapy should not be routinely discontinued before major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures Use caution in bronchospastic disease, cerebrovascular insufficiency, congestive heart failure, diabetes mellitus, hyperthyroidism/thyrotoxicosis, liver disease, renal impairment, peripheral vascular disease, myasthenic conditions Sudden discontinuance can exacerbate angina and lead to myocardial infarction Use in pheochromocytoma Increased risk of stroke after surgery Hypersensitivity reactions, including anaphylactic and anaphylactoid reactions, have been reported Cutaneous reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, and urticaria, have been reported Exacerbation of myopathy and myotonia has been reported Less effective than thiazide diuretics in black and geriatric patients May worsen bradycardia or hypotension; monitor HR and BP Avoid beta blockers without alpha1-adrenergic receptor blocking activity in patients with prinzmetal variant angina; unopposed alpha-1 adrenergic receptors may worsen anginal symptoms May induce or exacerbate psoriasis; cause and effect not established Prevents the response of endogenous catecholamines to correct hypoglycemia and masks the adrenergic warning signs of hypoglycemia, particularly tachycardia, palpitations, and sweating May cause or worsen bradycardia or hypotension Pregnancy category: C; intrauterine growth retardation, small placentas, and congenital abnormalities reported, but no adequate and well-controlled studies conducted Lactation: Use is controversial; an insignificant amount is excreted in breast milk Nonselective beta adrenergic receptor blocker; competitive beta1 and beta2 receptor inhibition results in decreases in heart rate, myocardial contractility, myocardial oxygen demand, and blood pressure Class 2 antidysrhythmic Bioavailability: 30-70% (food increases bioavailability) Onset: Hypertension, 2-3 wk; beta blockade, 2-10 min (IV) or 1-2 hr (PO) Duration: 6-12 hr (immediate release); 24-27 hr (extended release) Peak plasma time: 1-4 hr (immediate release); 6-14 hr (extended release) Solution: Most common solvents Additive: Dobutamine, verapamil Syringe: Inamrinone, milrinone Y-site: Alteplase, fenoldopam, gatifloxacin, heparin, hydrocortisone, sodium succinate, inamrinone, linezolid, meperidine, milrinone, morphine, potassium chloride, propofol, tacrolimus, tirofiban, vitamins B and C IV administration rate should not exceed 1 mg/min IV dose is much smaller than oral dose Give by direct injection into large vessel or into tubing of free-flowing compatible IV solution Continuous IV infusion generally is not recommended The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

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    Inderal Tablets is a brand of medicine containing the active ingredient. chin, hands; phaeochromocytoma; Fallot's Tetralogy; to prevent migraine headaches. Two beta blockers are currently FDA approved for use in the preventative treatment of migraine propranolol Inderal and Inderal LA and timolol Blocadren. Inderal LA is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches. Inderal LA is available in generic form.

    Beta Blockers in the Treatment of Migraine Of all the preventative medicines available across the United States, the drugs known as beta blockers are probably the most frequently prescribed. The "beta" refers to receptors on the blood vessels known as beta receptors. Beta blockers prevent the chemical interaction of certain chemicals with this receptor, hence, the term "beta blockers." Of this family of drugs, the most frequently used drug is Inderal, although others, such as Tenormin and Corgard, will also be used occasionally. Beta blockers were developed primarily for control of cardiac symptoms, but it was found coincidentally that these drugs had a remarkable effect on migraine prevention. After this chance observation was made, studies conducted in the late 1960s and early 1970s confirmed the improvement in migraine with treatment. The studies show that sixty to seventy percent of all migraine subjects experienced a decrease of more than fifty percent in the incidence and severity of their headaches when treated with one of these beta blockers. Two beta blockers are currently FDA approved for use in the preventative treatment of migraine: propranolol (Inderal and Inderal LA) and timolol (Blocadren). Propranolol is a beta blocker medication which is helpful in preventing migraine attacks in some patients. If a patient is having frequent attacks or severe, long-lasting attacks, it may be of help in cutting down the frequency of the attacks. However, it should be taken only under the careful supervision of a physician familiar with its use. A dose of propranolol up to 240 mg may be necessary. Inderal LA (60-80-120-160 mg) is a convenient one-a-day way to take the medicine. Inderal® can diminish endurance and tolerance to running and exercise, and it may take longer to accomplish previous goals. Immediate side effects can include diarrhea, tiredness, slowed pulse, and/or lowered blood pressure. Patients with bronchial asthma or other similar lung conditions, congestive heart failure or heart block should not use this agent.

    Inderal migraine

    Migraines Stop them before they start - Harvard Health Blog., Beta Blockers in the Treatment of Migraine - Newport Beach.

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  6. Dec 3, 2014. Inderal Propanolol is used to treat high blood pressure, a beta blocker. migraines, thickened heart muscle hypertrophic subaortic stenosis.

    • Inderal Propranolol - Side Effects, Dosage, Interactions - Drugs.
    • Common Side Effects of Inderal LA Propranolol Drug Center - RxList.
    • Migraine Treatment Update Page 5 - Practical Pain Management.

    Reviews and ratings for inderal when used in the treatment of migraine prevention. 29 reviews submitted. Although propranolol is still the drug of first choice for migraine prophylaxis, the optimal antimigraine dose of this drug is still unknown. The main aim of our study. Jan 17, 2018. The beta-blocking properties help to control heart rhythm, delay the start of chest pain, prevent migraines, and reduce tremors. It isn't fully.

     
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