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    RETIN-A Gel and Cream, containing tretinoin, are used for the topical treatment of acne vulgaris. RETIN-A Gel contains tretinoin (retinoic acid, vitamin A acid) in either of two strengths, 0.025% or 0.01% by weight, in a gel vehicle of butylated hydroxytoluene, hydroxypropyl cellulose and alcohol (denatured withbutyl alcohol and brucine sulfate) 90% w/w. RETIN-A (tretinoin) Cream contains tretinoin in one of three strengths, 0.1%, 0.05%, or 0.025% by weight, in a hydrophilic cream vehicle of stearic acid, isopropyl myristate, polyoxyl 40 stearate, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. Chemically, tretinoin is Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones. RETIN-A is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established. The drug belongs to the class of compounds called retinoid. The formulation of the drug is also referred to as all-trans retinoic acid (ATRA). It is a metabolite of naturally-occurring vitamin A. The retinoid metabolite of the drug acts by activating 3 nuclear receptors such as RARα, RARβ and RARγ. This action of the drug leads to growth and differentiation of epithelial cells, modification in the gene expression and protein synthesis. However, the precise mechanism of action of brand or generic Retin A Gel is not known. It is believed that the drug acts effectively in treating acne because it is able to modify the abnormal follicular-keratinization.

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