Plaquenil is also known as a treatment for malaria, a blood-borne parasite spread by mosquitoes in many tropical and sub-tropical environments. The usual dose is between one and two tablets per day (200 to 400 mg per day). When Plaquenil works, most patients start to feel improvement after 8-12 weeks. When patients start Plaquenil, doctors usually have them try it for 3 months before they assess the patient to determine if it is working. Chagas disease is treated with chloroquine Sudden blurry vision with plaquenil Plaquenil and methylprednisolone Side effects of Plaquenil that are different from Rheumatrex and Trexall include stomach pain or cramps, loss of appetite, weight loss, diarrhea, spinning sensation, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss. Re Plaquenil and Tinnitus. Reply #1 on November 18, 2014, PM. The ringing in my ears is a nuisance too. During the day when I am busy I can usually tune it out and it does not bother me so much. I guess I am just distracted from it if I am concentrating on doing things. At night is bothers me more. I mentioned ringing in my ears to my rheumy a few months back. He had me go to an ENT to rule out Meniere's. They told me that plaquenil can cause it, but he did not think that it was that. So, anyway, after my appt. they determined that I have severe high frequency hearing loss and that is what is causing the ringing in my ears. Plaquenil is considered to be pretty safe, but it can rarely damage the eyes. If it isn’t working at all after this time then it is usually stopped. Plaquenil and ringing in ears Why is ringing in the ears a side effect of., Plaquenil and Tinnitus Can you take plaquenil as neededHydroxychloroquine urticarial vasculitisHydroxychloroquine can it shrink spleenHydroxychloroquine surfactant deficiencySulfasalazine hydroxychloroquine and methotrexate Hi, Has anyone had any problems with adverse effects from Plaquenil? I take 200 mg twice per day for 2 1/2 months now. At first, I had GI upset which resolved, but for that past month, I have had blurry vision, severe headaches, weakness, ringing ears and dizziness. I quit taking it Sunday and called my rheumatologist Healthboards - Immune & Autoimmune - Lupus Plaquenil Toxicity. Plaquenil and tinnitus DailyStrength. Will you have Tinnitus with Plaquenil - eHealthMe. I have had ringing in my ears when I started taking Hydroxychloroquine. I had difficulty at work coz of the constant ringing in my ears. When I mentioned it to my rheumatologist she reduced the dose. After that I dint have any probs. Its better if you try and reduce the dose and see if it makes any difference. A few years ago I developed tinnitus ringing in the ears after being on 400mg./day of Plaquenil for 8 months. I had just had my hearing tested before this began and it was normal at the time. I called my audiologist and she said the tinnitus was a sign of ototoxicity and suggested I get off the med. or try reducing the dosage. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell.