Trametinib and hydroxychloroquine

Discussion in 'Canadian Pharcharmy Online' started by Crusty, 08-Mar-2020.

  1. shurik44 New Member

    Trametinib and hydroxychloroquine


    Researchers from Huntsman Cancer Institute (HCI) at the University of Utah have now come up with a potential new therapy for pancreatic cancer patients. The researchers have found that a new combination therapeutic approach can effectively fight the disease and prolong survival among patients.

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    Mar 17, 2019 Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Phase I Trial of Trametinib and Hydroxychloroquine in Patients With Advanced Pancreatic Cancer THREAD Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. METHODS Patients with stage IV metastatic melanoma and BRAF V600E mutations n = 11, 31-68 years of age were included. Treatment was with oral dabrafenib, 150 mg bid, trametinib, 2 mg/day, and HCQ, 400 mg to 600 mg bid.

    The results of the study were published in the latest issue of the journal The team has opened up the therapy for clinical trials at HCI as well as other centres across United States along with support from University of California, San Francisco, and Columbia University in New York. The therapy has shown promise in the laboratory set up and now is ready for use among human patients in its clinical trials.

    Trametinib and hydroxychloroquine

    Phase Ib/II study of hydroxychloroquine in combination with., Phase I Trial of Trametinib and Hydroxychloroquine in.

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  4. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.

    • Hydroxychloroquine Side Effects, Dosage, Uses, and More.
    • FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK..
    • Trametinib and Hydroxychloroquine in Treating Patients..

    Huntsman Cancer Institute, University of Utah Photo National Cancer Institute Investigators at the Huntsman Cancer Institute at the University of Utah are conducting a Phase I clinical trial to study the side effects and best dose of hydroxychloroquine when given together with trametinib MEKINIST ®, Novartis in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery. Trametinib and Hydroxychloroquine in Treating Patients With Pancreatic Cancer THREAD The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Hydroxychloroquine and chloroquine are medications traditionally prescribed to prevent or treat malaria infections. In certain countries and parts of the world where malaria is still present, a person can easily catch malaria from a seemingly insignificant mosquito bite.

     
  5. marina_flic Well-Known Member

    My husband has been taking Plaquenil (generic hydroxychloroquine) for almost 2 yrs., under a rheumatologist's care. He became very ill, and was diagnosed w/ viral meningial encephalitis. User Reviews for Hydroxychloroquine to treat. - Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus COVID-19 and Autoimmune Disease Risk It Depends on the.
     
  6. beavis XenForo Moderator

    You can also try eye drops and ointments that help keep your eyes wet, sometimes known as artificial tears. Hydroxychloroquine Plaquenil Side Effects & Dosage for. NHS Hospitals are under Pressure during COVID-19 Pandemic. Coronavirus drug facts From hydroxychloroquine to.
     
  7. cidarro Well-Known Member

    Hydroxychloroquine Tablets - FDA prescribing information. Mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. Hydroxychloroquine sulfate filmcoated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg.

    Hydroxychloroquine Uses, Dosage & Side Effects -
     
  8. Vampiresska Moderator

    How to Stop Yeast Infection – Stop Itching, Burning and Pain How to Stop Yeast Infection Burning, Pain, Discharge. As is the case with itchiness, other symptoms such as burning, pain and discharge are also going to be worse if the infection is severe. Itchiness, burning and pain are likely to be experienced by everyone infected by the fungus. Discharge is not a universal symptom.

    Infections with Plaquenil? DailyStrength