Ophthalmic surveillance was performed on patients in a multicenter clinical trial testing high-dose (1000 mg daily) hydroxychloroquine for advanced non–small cell lung cancer. The US Food & Drug Administration–recommended screening protocol included only visual acuity testing, dilated fundus examination, Amsler grid testing, and color vision testing. Chloroquine vs mefloquine Qt with chloroquine phosphate As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. Megan B. Goodman, Ari Ziskind, Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy, African Vision and Eye Health, 2015, 74, 1CrossRef; 19 Junyeop Lee, Joo Yong Lee, Hydroxychloroquine Retinopathy, Journal of Rheumatic Diseases, 2015, 22, 3, 140CrossRef Genetic Variants in Egyptian Patients Receiving HCQHydroxychloroquine HCQ The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Out of the 7 patients having exposure of at least 6 months, 2 developed retinal toxicity (at 11 and 17 months of exposure). In patients seen at Stanford, additional sensitive screening procedures were added at the discretion of the retinal physician: high-resolution spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF) imaging, Humphrey visual field (HVF) testing, and multifocal electroretinography (mf ERG). Hydroxychloroquine-mediated retinopathy Hydroxychloroquine-Induced Myopathy Request PDF, Incidence of hydroxychloroquine retinopathy in 1,207. Hydroxychloroquine long term usePlaquenil arthritis meds Retinopathy a case report and literature review Seong Joon Ahn*†, Jooyoung Joung†, Sang Hyup Lee and Byung Ro Lee* Abstract Background Cystoid macular oedema CMO is an uncommon complication associated with hydroxychloroquine HCQ retinopathy threatening central vision. We report a patient with HCQ retinopathy and CMO, for which an Intravitreal dexamethasone implant therapy for the.. Genetic Variants in Egyptian Patients Receiving HCQ.. Hydroxychloroquine An old drug with new relevance.. Abstract. The 4-aminoquinolines are weak bases that are completely absorbed from the gastrointestinal tract, sequestered in peripheral tissues, metabolized in the liver to pharmacologically active by-products, and excreted via the kidneys and the feces. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. Acute zonal occult outer retinopathy AZOOR is a retinal disease first described by Gass in 1992; reporting on 13 cases that shared the following features rapid loss of one or more large zones of outer retinal function, minimal fundus changes, electroretinographic abnormalities, and permanent visual field loss that was associated with delayed development of visible atrophic changes in the.