Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil hypercalcemia Hydroxychloroquine cystic fibrosis U87 chloroquine in vivo Plaquenil and uveitis Suppression 5 mg/kg calculated as base orally on exactly the same day each week; the dose should not exceed 400 mg regardless of weight Comments-Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 10 mg/kg calculated as base may be taken in 2 divided doses 6 hours apart. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage. For children and infants, the dose is based on weight. Usually, 5 mg per kg of body weight about 2.3 mg per pound once weekly is recommended, not to exceed the normal adult dosage. Plaquenil comes only in adult-strength tablets, which taste extremely bitter when crushed or chewed. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil dosage mg kg Taking Plaquenil for Various Conditions and Treatment Tips, Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Can hydroxychloroquine affect lftsSynthesis of chloroquine phosphatePlaquenil for ra reviewsPlaquenil for chronic urticariaPlaquenil screening 2018 Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate and concurrent macular disease Plaquenil hydroxychloroquine sulfate dosing, indications.. Plaquenil Dosage - eMedTV Health Information Brought To Life. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. Plaquenil film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Melton & Thomas describe the typical safe Plaquenil dosage this way The usual dosage is two 200mg tablets per day. This is generally a "safe" dose for patients having a lean body weight of at least 135 lbs. The generally-regarded safe dosage is 6.5mg/kg/qd, thus the 135 lb. safety threshold. The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. These guidelines were established to minimize the likelihood of permanent vision loss related to hydroxychloroquine retinopathy.