Chloroquine diphosphate salt autophagy

Discussion in 'Canada Pharmacy' started by nelli_dream, 17-Mar-2020.

  1. aleksei-mail Well-Known Member

    Chloroquine diphosphate salt autophagy


    It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic p H, and prevents fusion of endosomes and lysosomes. TLR7/8-Mediated Activation of Human NK Cells Results in Accessory Cell-Dependent IFN- Production.

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    Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been. Chloroquine diphosphate is used as an antimalarial drug and also functions to increase sensitivity of tumor cells to radiation and chemotherapy via inducing autophagy 1. Chloroquine diphosphate has been reported as an adjuvant for radiation and chemotherapy for inducing cell autophagy to anti-cancer cells proliferation or metastasis 2. Autophagy is a key pathway in the development of endocrine resistance in breast cancer, and targeting autophagy can reverse antiestrogen resistance. Chloroquine, an anti-malarial drug, inhibits autophagy by preventing degradation of autolysosomes.

    Moreover, Chloroquine inhibits autophagy as it raises the lysosomal p H, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation [4]. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes [2, 3], such as the signaling of intracellular TLRs.

    Chloroquine diphosphate salt autophagy

    Chloroquine diphosphate Autophagy Inhibitor MedChemExpress, APExBIO - Chloroquine diphosphateAntimalarial drugCAS.

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    Purpose Estrogen receptor-α ERα-targeted therapies including tamoxifen TAM or Faslodex ICI are used to treat ER+ breast cancers. Up to 50% of tumors will acquire resistance to these interventions. Autophagy has been implicated as a major driver of antiestrogen resistance. We have explored the ability of chloroquine CQ, which inhibits autophagy, to affect antiestrogen responsiveness. We have established a Drosophila melanogaster model to study glycogen autophagy in skeletal muscles, using chloroquine CQ to simulate a vacuolar myopathy that is completely dependent on the core autophagy genes. We show that autophagy is required for the most efficient degradation of glycogen in response to starvation. Chloroquine diphosphate salt C6628 - Product Information Sheet Author Sigma-Aldrich Corp. Subject This product is a member of the quinoline family with multiple applications. It was originally used as an antimalarial compound.

     
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