It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Chloroquine and primaquine treatment Aralen rheumatoid arthritis Chloroquine paludisme Chloroquine dose per kg Less common adverse effects of Plaquenil are drug-induced skin rashes. These rashes may consist of many small red bumps or bright red skin covering most of the body. The severity of the rash indicates to the clinician whether the drug needs to be stopped and even whether it will be tried again. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Plaquenil induced rash Hydroxychloroquine-induced dark butterfly rash in a., Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus. Plaquenil infoHydroxychloroquine side effects classSle hydroxychloroquine Background Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. Adverse Cutaneous Reactions to Hydroxychloroquine Are More Common in.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Plaquenil Oral Uses, Side Effects, Interactions, Pictures, Warnings.. I am starting to itch in my scalp, back, stomach, face and arms now. I think this rash is just starting, so I don't know if it will develope into hives or what. Could this be related to the plaquenil. I have had some weird hive like rashes in the past that I was not able to get biopsied for lupus, so I don't know if this could be the case or not. Drug-induced lupus should not be confused with drug side-effects, such as gastrointestinal, neurologic, or allergic symptoms that often occur after short-term therapy with various medications. These problems usually occur within a few hours or days of taking the medication. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative.