The fever is usually above 39 °C (102 °F) and sometimes reaching 40 °C (104 °F) and may be biphasic—lasting several days, breaking, and then returning. Fever occurs with the onset of viremia, and the level of virus in the blood correlates with the intensity of symptoms in the acute phase. Can you take potassium supplements while on plaquenil Psoriasis and plaquenil Plaquenil kidney transplant Chikungunya virus CHIKV is a mosquito-borne pathogen that has a major health impact in humans and causes acute febrile illness in humans accompanied by joint pains and, in many cases, persistent arthralgia lasting for weeks to years. Some patients were treated with chloroquine, because it is effective in treating certain forms of chronic arthralgia, particularly in the context of some auto-immune illnesses. Chloroquine may also inhibit viral replication. On chikungunya acute infection and chloroquine treatment. Chikungunya Disease and Chloroquine Treatment. Chikungunya is an arbovirus that is transmitted by the Aedes mosquito causing a febrile illness with periodic outbreaks in large parts of the. However, headache, insomnia and an extreme degree of exhaustion remain, usually about five to seven days. When Ig M, an antibody that is a response to the initial exposure to an antigen, appears in the blood, viremia begins to diminish. Chloroquine chikungunya Assessment of in vitro prophylactic and therapeutic efficacy., Chikungunya First Steps toward Specific Treatment and. Blood clots during period with plaquenilHydroxychloroquine mechanism of action medscapePlaquenil pronounce Many articles don't mention chloroquine at all. A few articles strongly recommend this Zhi 2020, Gao 2020 Chikungunya Virus Caveat Chloroquine was effective for chikungunya virus in vitro, but subsequently failed to work in primate model in fact, immunosuppressive effects of chloroquine actually increased viral levelsRoques et al 2018. COVID-19 - EMCrit Project. Chikungunya Disease and Chloroquine Treatment. Approaches to the treatment of disease induced by chikungunya.. We showed from ex-vivo studies in a sensitive model of cells culture to the viral infection that chloroquine provides a significant inhibition on the replication of the Chikungunya virus. This efficacy seemed also to be reached at a plasmatic concentration of similar order of magnitude as recommended for treating malaria with this drug. Chloroquine is also in trials as an antiretroviral for HIV-1/AIDS and is being considered in pre-clinical models as a potential agent against chikungunya and Zika. Several clinical trials still ongoing have attempted to establish the use chloroquine analogs in the prevention or treatment of several viral infections, including HIV, hepatitis, rabies, Chikungunya, Ebola virus disease, influenza A and B, and dengue viral infections Table 2.